ALTERATIONS IN VITAMIN D SIGNALLING AND METABOLIC PATHWAYS IN BREAST CANCER PROGRESSION: A STUDY OF VDR, CYP27B1 AND CYP24A1 EXPRESSION IN BENIGN AND MALIGNANT BREAST LESIONS VITAMIN D PATHWAYS UNBALANCED IN BREAST LESIONS

Abstract Background Breast cancer is a heterogeneous disease associated with different patient prognosis and responses to therapy.Vitamin D has been emerging as a potential treatment for cancer, as it has been demonstrated that it modulates proliferation, apoptosis, invasion and metastasis, among others.It acts mostly through the Vitamin D receptor

ABSTRAK Berbagai model evapotranspirasi potensial (ETp) telah dikembangkan, mulai dart model-model yang sederhana sampai dengan model-model yang kompleks membutuhkan konversi-konversi dan perhitungan rumit.Model ETp Penman termasuk model yang kompleks membutuhkan parameter-parameter iklim yang cukup banyalcyaitu: suhu udara, kelembaban relatif(rela

The blood-brain barrier (BBB) is a major hurdle for wx gloves the development of systemically delivered drugs against diseases of the central nervous system (CNS).Because of this barrier there is still a huge unmet need for the treatment of these diseases, despite years of research efforts across the pharmaceutical industry.Novel therapeutic entiti

Disodium molybdenum dioxide diarsenate, Na2MoO2As2O7, has been synthesized by a solid-state reaction.The structure is built up from MoAs2O12 linear units sharing corners to form a three-dimensional framework containing tunnels running along the a-axis direction in which the Na+ cations are located.In this framework, the lime sizzler firebush for sa

Rice variety differentiation was based on morphological descriptors (DUS) before the advent of genomic and proteomic technology.DNA fingerprinting is becoming an important molecular marker approach because of its wide application in varietal protection, classification, may pride peach tree and conflict settlement.In the present study, genetic diver